HIV replication is associated with increased severity of liver biopsy changes in HIV-HBV and HIV-HCV co-infection

J Audsley; P du Cros; Z Goodman; C Mclean; A Mijch; SR Lewin; J Sasadeusz

Journal article

HIV replication is associated with increased severity of liver biopsy changes in HIV-HBV and HIV-HCV co-infection

J Audsley, P du Cros, Z Goodman, C Mclean, A Mijch, SR Lewin, J Sasadeusz

Journal of Medical Virology | WILEY | Published : 2012

DOI: 10.1002/jmv.23236

Abstract

Histological parameters were assessed in liver biopsies (n=48) performed in patients co-infected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) and/or hepatitis C virus (HCV) in order to evaluate factors which were associated with significant liver disease. Necroinflammation and fibrosis was scored by the Ishak classification system, and binary logistic regression analysis was used to assess HIV and antiretroviral-related determinants of necroinflammation and fibrosis. A total of 46 biopsies were included; 33 were from HIV-positive patients co-infected with HCV and 15 biopsies were from HIV-positive patients co-infected with HBV. One HIV-positive patient was co-infected ..

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University of Melbourne Researchers

Jennifer Audsley Author

Catriona McLean Author

Sharon Lewin Author

Joseph Sasadeusz Author

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Grants

Awarded by National Institute of Health

Funding Acknowledgements

Grant sponsor: NHMRC Centre for Clinical Research Excellence in Infectious Diseases; Grant sponsor: University of Melbourne; Grant sponsor: National Institute of Health; Grant number: RO1 A1060449; Grant sponsor: Alfred Foundation.